樊玲玲
2018-11-09 10:44  

姓名:樊玲玲

学历:博士研究生

职称:副教授

导师资格: 硕士研究生导师

主要研究方向:活性先导化合物及其结构优化

个人简介:2013年毕业于西北农林科技大学,同年就职于欧洲杯下单平台有机化学教研室,主持贵州省科技厅、贵州省教育厅、贵州省卫生厅等各类基金项目5项,发表论文19篇,其中SCI论文12篇,申请国家专利4项。

科研项目:

二氢吲哚乙酸类抗糖尿病药物的设计、合成及活性研究,黔科合J[2014]2020号,贵州省科技厅,2014.8-2017.8

吲哚类杂环化合物的合成及其降糖活性研究,院基金合同字第012号,博士启动基金,2014.9-2016.9

具有PPARγ拮抗活性的树豆酮酸A衍生物的设计、合成及降糖活性研究,黔教合KY[2014]300号,贵州省教育厅,2014.11-2017.11

川芎嗪衍生物的合成机器抗血小板凝集活性研究,gzwjkj2016-1-050贵州省卫生厅,2016.10-2019.10

川芎嗪衍生物ZT-5ZT-16治疗缺血性脑卒中的成药性研究,黔科合支撑[2017]2835,科技厅社发攻关,2017.7-2020.7

发表论文:

[1] Lingling Fan,Jianta Wang,Xiao Ma,Wan Xiao,Zhiyan Li,Gang Zhong,Lei Tang*,Haoshu Wu*. Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25(7): 1500-1505.

[2] Lingling Fan, Xiaoyan Zhi, Zhiping Che, Hui Xu*. Insight into 2α-chloro-2′(2′,6′)-(di)halogenopicropodophyllotoxins reacting with carboxylic acids mediated by BF3·Et2O[J]. Scientific Reports, 2015, 5: 16285.

[3] Lingling Fan,Yong Guo, Xiaoyan Zhi, Xiang Yu, Hui Xu*, Stereoselective synthesis of 2alpha-chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, Mythimna separate walker[J]. Journal of Agricultural and Food Chemistry,2014,62(17):3726-3733.

[4] Lingling Fan, Zhi-ping Che, Rui Zhang, Xiang Yu, Xiao-yan Zhi, Hui Xu*. Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl-aryl coupling reaction[J]. Molecular Diversity, 2012, 16(2): 415-421.

[5] LingLing Fan, Ning Huang, Ruige Yang, Shuzhe He, Liumeng Yang, , Hui Xu*. Yongtang Zheng. Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro[J]. Letters in Drug Design & Discovery, 2012, 9(1): 44-47.

[6] Hui Xu *, LingLing Fan. Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives[J]. European Journal of Medicinal Chemistry, 2011, 46(5): 1919-1925.

[7] Hui Xu*, LingLing Fan. Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole [1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro[J]. European Journal of Medicinal Chemistry, 2011, 46(1): 364-369.

[8] Lingling Fan, Wuqing Liu, Hui Xu*, Liumeng Yang, Min Lv, Yongtang Zheng. Anti human immunodeficiency virus-1 (HIV-1) agents 3. synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles[J]. Chemical & Pharmaceutical Bulletin, 2009, 57(8): 797-800.  

[9] Lingling Fan, Wuqing Liu, Hui Xu*, Liumeng Yang, Min Lv, Yongtang Zheng. Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro. Letters in Drug Design & Discovery, 2009, 6(3): 178-190.

[10 Hui Xu*, LingLing Fan. One-pot N-arylation of indoles directly from N-arylsulfonylindoles via consecutive deprotection and SNAr reactions with activated aryl halides[J]. Chemical & Pharmaceutical Bulletin, 2009, 57(3): 321-323. (IF:1.7)

[11] Hui Xu*, LingLing Fan. Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions[J]. Chemical & Pharmaceutical Bulletin, 2008, 56(10): 1496-1498.  

[12] 樊玲玲,曹俊,李永,崔杏,王建塔,汤磊.4--5,6-二氢吡啶并[3,4-d]嘧啶-7(8H)-羧酸叔丁酯的合成[J]. 化学试剂, 2016, 38(04): 371-373.

[13] 樊玲玲,李毅,吴晓芳,李永,张珏.川芎嗪衍生物的设计、合成及抗血小板凝集活性研究[J]. 化学通报, 2018, 81(06): 543-547.


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